WebMapping the Phospho-dependent ALK Interactome to Identify Novel Components in ALK Signaling Author: Farzaneh Aboualizadeh, Zhong Yao, Jikui Guan, Luka Drecun, Shivanthy Pathmanathan, Jamie Snider, Ganesh Umapathy, Max Kotlyar, Igor Jurisica, Ruth Palmer, Igor Stagljar Source: Journal of molecular biology 2024 v.433 no.23 pp. 167283 ISSN: Web19 Nov 2024 · Introduction. Protein kinases are one of the largest families in the human genome and play critical roles in regulation of different cellular functions including various signaling pathways.1, 2 Dysfunction of protein kinases is associated with a wide range of human diseases such as cancer, making them important therapeutic targets. 3 Receptor …
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Web24 Feb 2024 · Pathmanathan S 1, Aboualizadeh F 1, Lyakisheva A 1, Yao Z 1, Wang Y 5, Joseph B 6, Aman ... , 1 Adriana Vučetić, 1 Victoria Wong, 1 Brigitte Thériault, 7 Nhu-An Pham, 5 Jin H Park, 8, 9 Alessandro Datti, 10, 11 Jenny Wang, 10 Shivanthy Pathmanathan, 1, 6 Farzaneh Aboualizadeh, 1 Anna Lyakisheva, 1 Zhong Yao, 1 Yuhui Wang, 5 Babu … WebShivanthy Pathmanathan. Graduate Student. [email protected]. I graduated with a B.Sc in Molecular Genetics and Biochemistry from the University of … formula de winter
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Web1 Feb 2024 · In this review, we discuss recent integrative multiple omics approaches for understanding and modulating previously identified ‘undruggable’ targets such as members of the RAS family, MYC, TP53, and various E3 ligases and deubiquitinases. We describe how these technologies have revolutionized drug discovery by overcoming an array of ... Web24 Feb 2024 · Punit Saraon, Shivanthy Pathmanathan, … Igor Stagljar. Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations. 10 November 2024. WebYear. Receptor tyrosine kinases and cancer: oncogenic mechanisms and therapeutic approaches. P Saraon, S Pathmanathan, J Snider, A Lyakisheva, V Wong, I Stagljar. … difficult hiking trails in burlington vermont