Salarin c synthesis
WebNov 26, 2024 · Abstract. A convergent strategy for the synthesis of dideoxysalarin C (3) as a potential intermediate for the total synthesis of the marine macrolide salarin C (1) is … WebAug 17, 2024 · Europe PMC is an archive of life sciences journal literature. Search life-sciences literature (41,975,589 articles, preprints and more) (41,975,589 articles, preprints and more)
Salarin c synthesis
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WebDOI: 10.1016/J.TETLET.2008.05.038 Corpus ID: 96996339; Salarin C, a new cytotoxic sponge-derived nitrogenous macrolide @article{Bishara2008SalarinCA, title={Salarin C, a new cytotoxic sponge-derived nitrogenous macrolide}, author={Ashgan Bishara and Amira Rudi and Maurice Aknin and Drorit Neumann and Nathalie Ben-Califa and Yoel Kashman}, … WebA convergent strategy for the synthesis of dideoxysalarin C (3) as a potential intermediate for the total synthesis of the marine macrolide salarin C (1) is described.
WebApr 20, 2024 · The eastern section of the macrocyclic marine natural product salarin C from the sponge Fascaplysinopsis sp. was synthesized employing a halogen dance reaction to … WebThe synthesis of the macrocyclic core of the cytotoxic natural product salarin C from the sponge Fascaplysinopsis sp. is described, with the two epoxides being replaced by alkene …
WebApr 20, 2024 · The synthesis was inspired by Kashman's hypothesis on the biomimetic oxidation of salarin C to salarin A. Clean conversion to the triacylamine partial structure of salarin A occurred on treatment with photochemically generated singlet oxygen. Thus, a Wasserman-type oxidative rearrangement is chemically possible in this case. WebWhile salarin C (SalaC) is a potent marine cytotoxin, Kashman demonstrated that congeners which had undergone Wasserman rearrangement exhibit little to no cytotoxicity. Given …
WebFeb 1, 2012 · Salarin B's structure (2), based on the structure of salarin J (10), is now amended to also incorporate the C-14 to -17 THF ring system. All compounds were …
WebOct 24, 2024 · Mimicking the conversion of salarin C to salarin A, the trisubstituted oxazole unit embedded in the 17-membered ring underwent photooxidation on treatment with … shoe repair westfield san francisco centreWebJul 7, 2008 · A novel nitrogenous macrolide, designated salarin C (3), was isolated from the Madagascan sponge Fascaplysinopsis sp. The structure of the compound was elucidated by interpretation of MS and 1D and 2D NMR spectra.Salarin C is closely related to salarin A and is considered to be the precursor of salarins A and B (1,2).Air oxidation was found to … shoe repair west chesterWebNov 2, 2024 · The synthesis of the macrocyclic core of the cytotoxic natural product salarin C from the sponge Fascaplysinopsis sp. is described, with the two epoxides being … shoe repair welwyn garden cityWebThe synthesis of the macrocyclic core of the cytotoxic natural product salarin C from the sponge Fascaplysinopsis sp. is described, with the two epoxides being replaced by alkene moieties. In the key step, ring-closing metathesis exclusively afforded the (E)-product. racheal flannery louisvilleWebNov 26, 2024 · A convergent strategy for the synthesis of dideoxysalarin C (3) as a potential intermediate for the total synthesis of the marine macrolide salarin C (1) is described. The macrolactone core of 3 ... racheal cooper university of richmondWebA convergent strategy for the synthesis of dideoxysalarin C (3) as a potential intermediate for the total synthesis of the marine macrolide salarin C (1) is described. The … racheal eaganWebNov 12, 2013 · In the course of studies on bioactive metabolites from marine fungi, a new 10-membered lactone, named penicillinolide A (1) was isolated from the organic extract of Penicillium sp. SF-5292 as a potential anti-inflammatory compound. The structure of penicillinolide A (1) was mainly determined by analysis of NMR and MS data and Mosher’s … racheal edwards lmft