2024 Mouse klotho protein

Mouse klotho protein

Author: lkit

August undefined, 2024

Nettetbeta-Klotho, a newly described membrane protein, regulates bile acid synthesis. Fibroblast growth factor-15 (FGF-15) and FGF receptor-4 (FGFR4) knockout mice share a similar phenotype with beta-Klotho-deficient mice. FGF-15 secretion by the intestine regulates hepatic bile acid biosynthesis. Nettet27. aug. 2024 · Klotho has been recognized as a gene involved in the aging process in mammals for over 30 years, where it regulates phosphate homeostasis and the activity of members of the fibroblast growth factor (FGF) family. The α-Klotho protein is the receptor for Fibroblast Growth Factor-23 (FGF23), regulating phosphate homeostasis and …

Parishin alleviates vascular ageing in mice by upregulation of …

Nettet9. apr. 2024 · Klotho is an anti-ageing protein that can attenuate ageing-related diseases to extend healthspan. 8, 9 α-Klotho declines with ageing in mice and humans. 10 … NettetKlotho acts as a cofactor for interaction of FGF-23 with FGF R1 (6). This interaction negatively regulates 1 alpha -hydroxylase, the rate-limiting enzyme in the synthesis of … barry callebaut belgium salmonella

Kl klotho [Mus musculus (house mouse)] - Gene - NCBI

NettetCompared with the control group, the expression level of Klotho protein in the kidney tissue of the aging group was significantly decreased (P < 0.01, ... The previous study of our group found that the expression and activity of SIRT1 decreased in the aorta of Klotho gene-deficient mice, which induced the formation of arteriosclerosis in mice. Nettet19. jan. 2012 · Klotho is a recently discovered anti-aging gene. The purpose of this study was to investigate whether klotho gene transfer attenuates superoxide production and oxidative stress in rat aorta smooth muscle (RASM) cells. RASM cells were transfected with AAV plasmids carrying mouse klotho full-length cDNA (mKL) or LacZ as a control. barry callebaut denmark aps

Soluble serum Klotho levels in healthy subjects. Comparison of …

Frontiers Klotho, Aging, and the Failing Kidney

Nettet8. aug. 2024 · Researchers discovered the klotho protein in 1997, when they found that diminished levels seemed to make the animals age faster. Conversely, mice genetically engineered to maintain elevated... Nettet6. nov. 1997 · A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin … suzuki x 650NettetKlotho-deficient mice show severe hyperphosphatemia and ectopic calcification of soft tissues due to excess vitamin D (2, 7). Both Klotho and Klotho-beta are cofactors for … barry callebaut ghana

"Nettet26291 56636 Ensembl ENSG00000105550 ENSMUSG00000030827 UniProt Q9NSA1 Q9JJN1 RefSeq (mRNA) NM_019113 NM_020013 RefSeq (protein) NP_061986 NP_064397 Location (UCSC) Chr 19: 48.76 – 48.76 Mb Chr 7: 45.26 – 45.26 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Fibroblast growth factor 21 is a … " - Mouse klotho protein

Mouse klotho protein

Klotho protects chromosomal DNA from radiation-induced damage

Nettet9. nov. 2024 · Klotho depletion in the CP caused by aging or experimental manipulation. (A) CP (arrow) in the lateral ventricle of a 4-mo-old WT mouse visualized by klotho immunostaining of a coronal brain section.(B) Images of confocal optical sections of CPs in the lateral ventricles of 4-mo-old WT and kl/kl mice immunostained for klotho (green) … Nettet3. mai 2006 · klotho mutant mice were originally described as a short-lived mouse model with premature aging-like disorders. The klotho gene responsible for these phenotypes encodes a type I membrane protein with a considerable similarity to β-glycosidase.klotho is predominantly expressed in tissues functioning in the regulation of calcium …

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NettetRecombinant Mouse Klotho beta Protein Bioactivity Recombinant Mouse Klotho beta (Catalog # 2619-KB) stimulates cell proliferation of the BaF3 mouse pro-B cell line transfected with human FGF RIIIc. The ED 50 for this effect is 0.2-1 µg/mL in the presence of Recombinant Human FGF-21 (Catalog # 2539-FG) and Heparin. Nettet11. jun. 2024 · The α -klotho expression was detected in both control kidneys and hearts. The primers for α -klotho and GAPDH mRNA are listed in Table 1. As shown in …

NettetWhen Recombinant Human FGF-21 ( 2539-FG) is immobilized at 1 µg/mL (100 µL/well), Recombinant Human Klotho beta His-tag (Catalog # 5889-KB) binds with an ED 50 of 2.5-20 ng/mL. 1 μg/lane of Recombinant Human Klotho beta was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie ® … NettetPMID: 28259911. Thus, higher levels of FGF23 in kl/kl mouse may have a role to increase TNF-alpha production in would lesion independently of alpha-Klotho protein, and impair granulation formation and delay wound healing. PMID: 27037022. Klotho protein protects against diabetic nephropathy through multiple pathways.

Nettet7. feb. 2024 · Background: Calcific aortic valve disease (CAVD) is a chronic inflammatory disease. Soluble extracellular matrix (ECM) proteins can act as damage-associated molecular patterns and may induce valvular inflammation. Matrilin-2 is an ECM protein and has been found to elevate the pro-osteogenic activity in human aortic valve … Nettet13. jan. 2024 · Klotho is an age-extending, cognition-enhancing protein found to be down-regulated in aged mammals when age-related diseases start to appear. Low levels of …

Nettet6. nov. 1997 · A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, ... Kyte–Doolittle hydrophobicity analysis of mouse KL protein (GeneWorks ver2.5 ...

NettetKl þ /À mice had lower levels of Klotho protein in the plasma, kidney, and urine at baseline, which became undetectable after AKI (Figure 4 a-d). suzuki x6 250NettetGene Expression + Phenotype. Homozygous mutant mice have a short lifespan and growth retardation with one allele homeostatic imbalances and soft tissue calcification … suzuki x650Nettet22. jun. 2024 · Klotho-VS heterozygosity (KL-VShet) is associated with reduced risk of Alzheimer’s disease (AD). However, whether KL-VShet is associated with lower levels of pathologic tau, i.e., the key AD ... suzuki x69NettetObjective: Soluble serum Klotho is a new biomarker linked to chronic kidney disease, cardiovascular disease and diabetes. This study describes the evaluation and comparison of two different immunoassays and establishment of assay specific reference intervals in … barry callebaut ghana salaryNettet22. mar. 2024 · Klotho inhibits the formation of calcium oxalate stones by regulating the Keap1-Nrf2-ARE signaling pathway. Ahmatjan B, et al. Int Urol Nephrol, 2024 Feb. … suzuki x6 carNettetKlotho protein is a β-glucuronidase capable of hydrolyzing steroid β-glucuronides. Two molecules are produced by the Klotho gene, a membrane bound form and a circulating … suzuki x6lNettetMouse myeloma cell line, NS0-derived mouse Klotho beta protein Phe53-Leu995, with a C-terminal 10-His tag Purity >90%, by SDS-PAGE visualized with Silver Staining and … barry callebaut india pvt ltd baramati