WebMar 31, 2024 · Background and objective: Denosumab is a valuable and safe therapy for skeletal disorders in adults and has received regulatory approval to treat osteoporosis and bone metastases. However, denosumab is not licensed for pediatric use due to a lack of high-quality prospective research on children. This study aimed to describe and discuss … WebMar 31, 2024 · Introduction. Denosumab, a monoclonal antibody against receptor activator for nuclear factor kappa B ligand (RANKL), has recently seen widespread use in the treatment of adult osteoporosis and the prevention of bone-related events of bone metastases due to its ability to reduce bone turnover, increase bone density, and …
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Denosumab in pediatric bone disorders and the role of RANKL …
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