웹2013년 3월 19일 · Terminalia chebula, native to Southeast Asia, is a popular medicinal plant in Ayurveda. It has been previously reported to have strong antioxidant and anti-inflammatory efficacy. In this study, we aimed to investigate if fruit extract from T. chebula might protect neuronal cells against ischemia and related diseases by reduction of oxidative damage and … 웹2024년 5월 26일 · Abstract. A chemoenzymatic strategy has been developed for the synthesis of bastadins 2, 3, and 6. The requisite dimeric dityrosine and isodityrosine building blocks …
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웹Bastadins isolated from the marine sponge Ianthella basta. Results and Discussion According to the first method, the triazene functionality of an appropriately substituted aryl can be used to facilitate its coupling to phenols.4 Subsequent to diaryl ether formation, this directing group could be reductively or hydrolytically removed. 웹Bastadins 1-7 (204)(205)(206)(207)(208)(209)(210)(211) were isolated from the Australian sponge I. basta, as antimicrobial agents against Gram positive organisms in 1980 (128,129). Their structures were determined by spectroscopic methods and alcoholic KOH hydrolysis. ... arberia books
Synthetic bastadins modify the activity of ryanodine receptors in …
웹Moreover, the same active bastadins at a concentration of 5 muM in the presence of ryanodine prevented a thapsigargin-induced increase in Ca(i). These results indicate that bastadins, … 웹2024년 6월 7일 · RyR-1 complex. Bastadins 5,7, and the newly identified isomer of bastadin 5, bastadin 19, show marked differ- ences in potency and efficacy toward activation of the binding of [3Hlryanodine. In physiological salt, bastadin 5 (5 p~) increases the ['Hlryanodine binding capacity of SR membranes 5-fold, by stabilizing the high affinity 웹2013년 3월 1일 · Bastadins-6, -9 and -16 isolated from the marine sponge Ianthella basta displayed in vitro cytostatic and/or cytotoxic effects in six human and mouse cancer cell lines. The in vitro growth inhibitory effects of these bastadins were similar in cancer cell lines sensitive to pro-apoptotic stimuli versus cancer cell lines displaying various levels of … arberia